Prof. Smadar Ben-Tabou de-Leon obtained her PhD degree at the Racah Institute of Physics, at the Hebrew University in Jerusalem, on the optical properties of thin layers of semiconductors. She then did her first post-doctorate fellowship on the use of porous silicon surfaces for the detection of neural activity, under the supervision of Prof. Amir Sa’ar at the Hebrew University. In her second post-doctorate at the lab of Prof. Eric Davidson at Caltech, she made the transition to developmental and evolutionary biology and investigated the regulatory networks that drive the development of the sea urchin embryo. In 2012 she started her own laboratory at the University of Haifa, where she studies the biological regulation of biomineralization in the sea urchin larva. Her lab discovered that the molecular control of the sea urchin larval skeleton is similar to the regulation of blood vessel formations in vertebrates and humans. This illuminates how biomineralization evolved rapidly by co-opting ancestral developmental programs for organic scaffolds. Prof. Ben-Tabou de-Leon is currently the head of the Department of Marine Biology at the Charney School of Marine Sciences. She has published more than 30 peer-reviewed papers in theoretical and applied physics and biological sciences. Her work significantly contributed to the understanding of the genetic and cellular regulation of developmental processes and to the evolution of biomineralization. She is an associate editor of Frontiers in Ecology and Evolution and Frontiers in Cell and Developmental Biology. She is married, has four kids, and two cats and in her spare time she likes playing Pokemon Go, jogging and hiking.
Dr. Tsvia Gildor graduated from the Biology department at the Technion with a Master's degree in Leishmaniasis. In her PhD, she studied the recognition of proteins by the ubiquitin degradation system under the supervision of Prof. Daniel Kornitzer at the Medicine faculty of the Technion. She then continued to study liver cirrhosis in mice and returned to Kornitzer's lab for a postdoctoral fellowship to build and study a Candida Albicans phosphatase/kinases overexpression library. In 2012, she joined Smadar Ben-Tabou de-Leon's lab, and they have been working together ever since.
She loves microscopy, molecular biology, sea urchins, and teaching students how to do their best science. She enjoys outreach to anyone interested in the Mediterranean Sea, science, or nature. She likes to hike with her family: her husband, three children, and two dogs. In her free time, she practices theater, Pilates, and participates in various social activities.
PhD Student
My name is Aleksei Tabachnik, I am Ole Hadash born in Moscow in 1997 and a year PhD student in the lab. I graduated from Lomonosov Moscow State University with a Bachelor's in Invertebrate Zoology in 2018 and a Master's in Biophysics in 2020. My work is focused on the role of Erk signalling in controlling biomineral growth and morphology during larval skeletogenesis of the Mediterranean sea urchin, Paracentrotus lividus. My hobbies include science fiction and skiing (although the last one is not very accessible).
My name is Prashant Tewari, and I am from India. I have a bachelor's degree in biotechnology. In my bachelor's thesis, I gained experience in plant tissue culture and cryopreservation, and I worked on the genetic stability analysis of cryopreserved Fragaria species. After that, I moved to the RED lab at Haifa University to pursue my master's degree. I am currently in the 2nd year of my PhD in marine biology. I am fascinated by how a single cell can develop into a multicellular organism. How is cell fate determined? What kind of regulation is taking place? My master's reserach focused on identifying actomyosin remodeling genes that play a key role in sea urchin skeletogenesis. My project aimed to understand how common actomyosin remodeling proteins such as Cdc42 and PAK regulate biomineral growth and morphology in invertebrates.
In my PhD Project I am trying to understand the calcium vesicles dynamics during active skeletal growth in sea urchin skeletogenesis cell culture using advancing imaging like Spinning Disc Confocal Microscopy. Altogether I get to use cool techniques like immunohistochemistry and gene cloning to study different genes and various type of imaging.
In the lab, you can find me humming Taylor Swift songs (even outside the lab). When I am not in the lab, I am either travelling to explore this beautiful country or dancing away at a party! Occasionally, you can find me with a book (I enjoy reading), or in the kitchen, as I love to show off my culinary skills by mastering scrumptious recipes.
Jan Vintr
Ph.D. student
My name is Jan Vintr and I have just arrived from the Czech Republic. I'm going to do very cool stuff soon.
My name is Aman Prakash and I am a second year Master student in the lab. I'm trying to raise sea urchin larvae to the settlement and morphogenesis stage. I plan to study the effect of environmental stressors on sea urchin growth.
Nirikshan Mandal
M.Sc. student
Hi, I am Nirikshan Mandal, a proud native of Kolkata, India. I hold a bachelor’s degree in Microbiology from Ramakrishna Mission Vidyamandira under the University of Calcutta and a master’s degree in Chemical and Molecular Biology from IIT Kharagpur earned through an Integrated M.Sc.-Ph.D. program in collaboration with IACS, Kolkata. My initial research delved into lipid dynamics in zebrafish embryos, employing advanced microscopy and molecular biology techniques. Currently, I am pursuing a second master’s degree in Marine Biology, where my work in the RED Lab focuses on the molecular dynamics of SM30 and SM50 proteins during sea urchin skeletogenesis. I'm trying to make fusion fluorescent skeletogenic proteins and observe their expression in live sea urchin embryos. I will later identify a skeletogenic enhancer and use it to drive expression specifically in the skeletogenic cells. My research involves a blend of molecular biology techniques, microinjections, and confocal microscopy. When I’m not immersed in the lab, you may find me supporting Barcelona in football, playing cricket and chess, or experimenting in the kitchen to create delicious meals.
Itamar David Mayshar
M.Sc. student
My name is Itamar David Mayshar and I have just arrived at the RED lab. I will soon be doing very cool stuff.
Nadine Awwad
M.Sc. student
My name is Nadine Awwad, and I am a first-year M.Sc. student in the RED Lab. I graduated with a B.Sc. in Marine and Environmental Sciences from the Ruppin Academic Center. My research explores how vesicle formation and trafficking contribute to sea urchin skeletogenesis, with a focus on how disruptions in these processes affect biomineralization. I am a massive cat person. I love spending my time with family and it leisure time, I play tennis.
My name is Daniel Goloe, and I am from Ghana. I did my bachelor's in agriculture biotechnology. For my bachelor's research project, I work on the somatic embryogenesis of Irvingia gabonensis. Then I moved to Israel for my masters' studies. In My MSc studies at the RED lab, I focused on the Transforming growth factor Beta (TGF-β), and its role in sea urchin’s larval skeletogenesis. The Transforming Growth Factor Beta signalling plays a crucial role in bone formation in vertebrates. The TGF-β pathway is highly conserved in the animal kingdom, which makes it intriguing to study its role in biomineralization in invertebrates’ model systems. My findings were pulished in a paper in Genesis. When not in the lab I like to spend time listening to African music and catching up with my friends.
My name is Majed Layous, and I have just graduated from the RED lab.. Development biology has always fascinated me. How does a single cell become a multicellular organism? How does the genetic code drive morphogenesis? My curiosity about these questions led me to join the laboratory of Prof. Smadar Ben Tabou de-Leon, where I investigate the molecular mechanisms that control developmental processes. I joined the lab in 2017 as a master's student and then stayed to continue my PhD. In the lab, I study the role of mechansensing in sea urchin skeletogenesis and my findings were published in a very cool paper in PNAS. I hope that my work will illuminate the molecular mechanisms that sense environmental stiffness and translate it into the modulation of skeletal morphology and skeletogenic gene regulatory network.